Uncoupling mechanism and redox regulation of mitochondrial uncoupling protein 1 (UCP1)
نویسندگان
چکیده
منابع مشابه
The mitochondrial uncoupling protein UCP1: a gated pore.
The uncoupling protein UCP1 is a member of a superfamily of homologous proteins formed by the mitochondrial metabolite transporters. Although they act in vivo as carriers, under specific experimental conditions some of these transporters have been shown to behave as channels. This dual transport operation suggests that these carriers are likely to be formed by two differentiated functional and ...
متن کاملFatty acids change the conformation of uncoupling protein 1 (UCP1).
UCP1 catalyzes proton leak across the mitochondrial inner membrane to disengage substrate oxidation from ATP production. It is well established that UCP1 is activated by fatty acids and inhibited by purine nucleotides, but precisely how this regulation occurs remains unsettled. Although fatty acids can competitively overcome nucleotide inhibition in functional assays, fatty acids have little ef...
متن کاملOn the mechanism of mitochondrial uncoupling protein 1 function.
Native uncoupling protein 1 (UCP 1) was purified from rat mitochondria by hydroxyapatite chromatography and identified by peptide mass mapping and tandem mass spectrometry. Native and expressed UCP 1 were reconstituted into liposomes, and proton flux through UCP 1 was shown to be fatty acid-dependent and GDP-sensitive. To investigate the mechanism of action of UCP 1, we determined whether hydro...
متن کاملCircadian Variations of Serum Mitochondrial Uncoupling Protein 1 (UCP1) Levels and Rectal Temperature in Capra Hircus
Background: The daily rhythm of body temperature is an important process to be studied not only to advance knowledge on the temporal variability of thermal homeostasis but also has a means to facilitate the study of biological rhythmicity in general. The aim of the present study was to study the daily rhythm of rectal temperature and the changes in the serum levels of mitochondrial uncoupling p...
متن کاملOverexpression of mitochondrial uncoupling protein 1 (UCP1) induces a hypoxic response in Nicotiana tabacum leaves
Mitochondrial uncoupling protein 1 (UCP1) decreases reactive oxygen species production under stress conditions by uncoupling the electrochemical gradient from ATP synthesis. This study combined transcriptome profiling with experimentally induced hypoxia to mechanistically dissect the impact of Arabidopsis thaliana UCP1 (AtUCP1) overexpression in tobacco. Transcriptomic analysis of AtUCP1-overex...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Bioenergetics
سال: 2019
ISSN: 0005-2728
DOI: 10.1016/j.bbabio.2018.11.007